X-ray crystallography reveals insulin lisargine structure and mechanisms of glucose regulation

Abstract The development of effective and safe insulin analogs remains pivotal in advancing diabetes management. This study addresses the limitations of existing insulin therapies by introducing insulin lisargine, a novel long-acting insulin analog that resolves impurity formation associated with tr...

Full description

Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Zhu Zhu, Zhiming Zheng, Han Wang, Li Wang, Qingrong Yang, Zhou Wei, Peng Wang
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-09-01
Subjects:	Insulin lisargine X-ray crystallography Glucose Safety
Online Access:	https://doi.org/10.1038/s41598-025-07243-8