Leukemic conversion involving RAS mutations of type 1 CALR-mutated primary myelofibrosis in a patient treated for HCV cirrhosis: a case report

Somatic frameshift mutations in exon 9 of calreticulin (CALR) gene are recognized as disease drivers in primary myelofibrosis (PMF), one of the three classical Philadelphia-negative myeloproliferative neoplasms (MPNs). Type 1/type 1-like CALR mutations particularly confer a favorable prognostic and...

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الحاوية / القاعدة:	Frontiers in Oncology
المؤلفون الرئيسيون:	Petruta Gurban, Cristina Mambet, Anca Botezatu, Laura G. Necula, Ana I. Neagu, Lilia Matei, Ioana M. Pitica, Saviana Nedeianu, Mihaela Chivu-Economescu, Coralia Bleotu, Marius Ataman, Gabriela Mocanu, Carmen Saguna, Anca G. Pavel, Danae Stambouli, Elise Sepulchre, Gabriela Anton, Carmen C. Diaconu, Stefan N. Constantinescu
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2023-09-01
الموضوعات:	primary myelofibrosis (PMF) hepatitis C virus (HCV) cirrhosis type 1 calreticulin (CALR) targeted next-generation sequencing (NGS) NRAS acquired uniparental disomy (aUPD)
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1266996/full