CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer

Abstract Elevated squalene epoxidase (SQLE) levels in bladder cancer cells drive abnormal cholesterol accumulation, contributing to malignancy, invasion, and resistance to immunotherapy. Here, we introduce a hollow CuO nanoparticle-based nanotherapeutic, termed CuOTeDsP, which is PEGylated and co-lo...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Journal of Nanobiotechnology
المؤلفون الرئيسيون: Hai Cai, Panpan Xue, Siyuan Liu, Yaxin Ma, Xuemei Zeng, Shuangqian Yan, Ning Xu
التنسيق: مقال
اللغة:الإنجليزية
منشور في: BMC 2025-07-01
الموضوعات:
Cholesterol metabolism
SQLE
Cuproptosis
Bladder cancer
Immunotherapy
الوصول للمادة أونلاين:https://doi.org/10.1186/s12951-025-03609-2

الانترنت

https://doi.org/10.1186/s12951-025-03609-2

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