Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats

Oxidative stress and inflammation damage play pivotal roles in vascular dementia (VaD). Trimethylamine N-oxide (TMAO), an intestinal microbiota-stemming metabolite, was reported to promote inflammation and oxidative stress, involved in the etiology of several diseases. Still, these effects have not...

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Bibliographic Details

Published in:	Cells
Main Authors:	Yang Deng, Junqing Zou, Ye Hong, Qiang Peng, Xinxin Fu, Rui Duan, Jie Chen, Xiangliang Chen
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	trimethylamine N-oxide SIRT1 inflammation oxidative stress synaptic plasticity vascular dementia
Online Access:	https://www.mdpi.com/2073-4409/11/22/3650