Metabolic Functions of Biliverdin IXβ Reductase in Redox-Regulated Hematopoietic Cell Fate

Cytoprotective heme oxygenases derivatize heme to generate carbon monoxide, ferrous iron, and isomeric biliverdins, followed by rapid NAD(P)H-dependent biliverdin reduction to the antioxidant bilirubin. Recent studies have implicated biliverdin IXβ reductase (BLVRB) in a redox-regulated mechanism of...

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Bibliographic Details
Published in:Antioxidants
Main Authors: Wadie F. Bahou, Natalia Marchenko, Natasha M. Nesbitt
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Subjects:
megakaryocyte
erythroid development
antioxidant
cytoprotection
Online Access:https://www.mdpi.com/2076-3921/12/5/1058

Internet

https://www.mdpi.com/2076-3921/12/5/1058

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