Inhibition of OXPHOS induces metabolic rewiring and reduces hypoxia in murine tumor models

Introduction: Tumor hypoxia is a feature of many solid malignancies and is known to cause radio resistance. In recent years it has become clear that hypoxic tumor regions also foster an immunosuppressive phenotype and are involved in immunotherapy resistance. It has been proposed that reducing the t...

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Bibliographic Details

Published in:	Clinical and Translational Radiation Oncology
Main Authors:	Daan F. Boreel, Anne P.M. Beerkens, Sandra Heskamp, Milou Boswinkel, Johannes P.W. Peters, Gosse J. Adema, Paul N. Span, Johan Bussink
Format:	Article
Language:	English
Published:	Elsevier 2024-11-01
Subjects:	Hypoxia Metabolism OXPHOS IACS-010759 Metformin Atovaquone
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405630824001526