SKF-38393 regulates the expression of glutamic acid decarboxylase 67 via heparanase-1 in 6-hydroxydopamine-induced neurodegeneration

Abstract Dopamine (DA) plays an essential role in regulating γ-aminobutyric acid (GABA) neurons in the brain. This study aimed to investigate the effects of DA receptor agonists on the expression of glutamic acid decarboxylase 67 (GAD67) in the context of 6-hydroxydopamine (6-OHDA)-induced dopaminer...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Sijoon Lee, Munki Kim, Soo-Eun Sung, Gonsup Kim, Chungkil Won
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Subjects:
Dopamine receptors
GAD67
SKF38393
Heparanase-1
Tyrosine hydroxylase
Online Access:https://doi.org/10.1038/s41598-025-11672-w

Internet

https://doi.org/10.1038/s41598-025-11672-w

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