Cryo-EM structure of small-molecule agonist bound delta opioid receptor-Gi complex enables discovery of biased compound

Abstract Delta opioid receptor (δOR) plays a pivotal role in modulating human sensation and emotion. It is an attractive target for drug discovery since, unlike Mu opioid receptor, it is associated with low risk of drug dependence. Despite its potential applications, the pharmacological properties o...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Lin Cheng, Zhuang Miao, Sicen Liu, Zhe Li, Hong Fu, Chanjuan Xu, Shilong Hu, Chang Zhao, Yuxuan Liu, Tiantian Zhao, Wencheng Liu, Heli Wang, Runduo Liu, Wei Yan, Xiangdong Tang, Jianfeng Liu, Zhenhua Shao, Bowen Ke
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-09-01
Online Access:	https://doi.org/10.1038/s41467-024-52601-1