A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death

Highlights CD73 is the key ectoenzyme involved in the generation of AMP-derived adenosine, which contributes to immunosuppression in the MM BM milieu. Blocking CD73 activity with a potent, selective, orally bioavailable CD73 inhibitor ORIC-533 decreases adenosine generation, overcomes immune suppres...

詳細記述

書誌詳細

出版年:	Blood Cancer Journal
主要な著者:	Arghya Ray, Ting Du, Xueping Wan, Yan Song, Sindhu C. Pillai, Md. Abu Musa, Teng Fang, Jared Moore, Brian Blank, Xiaohui Du, Xi Chen, Robert Warne, Dena Sutimantanapi, Fang Lui, Tatiana Zavorotinskaya, Christophe Colas, Lori Friedman, Melissa R. Junttila, Dharminder Chauhan, Kenneth C. Anderson
フォーマット:	論文
言語:	英語
出版事項:	Nature Publishing Group 2024-04-01
オンライン･アクセス:	https://doi.org/10.1038/s41408-024-01019-5