Chemotherapy-induced niche perturbs hematopoietic reconstitution in B-cell acute lymphoblastic leukemia

Abstract Background Considerable efforts have been devoted toward the uncovering of the molecular mechanisms underlying the maintenance of hematopoietic stem cells (HSCs) by the normal bone marrow (BM) niche. Previously, we demonstrated that a chemotherapy-induced niche, which is mainly composed of...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Chao Tang, Ming-Hao Li, Ya-Li Chen, Hui-Ying Sun, Sheng-Li Liu, Wei-Wei Zheng, Meng-Yi Zhang, Hui Li, Wei Fu, Wen-Jun Zhang, Ai-Bin Liang, Zhong-Hua Tang, Deng-Li Hong, Bin-Bing S. Zhou, Cai-Wen Duan
Format:	Article
Language:	English
Published:	BMC 2018-08-01
Subjects:	Acute lymphoblastic leukemia; chemotherapy-induced niche Hematopoietic reconstitution Hematopoietic stem cells Mesenchymal stem cells
Online Access:	http://link.springer.com/article/10.1186/s13046-018-0859-3