Impact of mouse model tumor implantation site on acquired resistance to anti-PD-1 immune checkpoint therapy

IntroductionThe use of tumor subcutaneous (SC) implantations rather than orthotopic sites is likely to induce a significant bias, in particular, in the field of immunotherapy.MethodsIn this study, we developed and characterized MC38 models, implanted subcutaneously and orthotopically, which were eit...

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書誌詳細

出版年:	Frontiers in Immunology
主要な著者:	Morgane Denis, Doriane Mathé, Manon Micoud, Pierre-Antoine Choffour, Chloé Grasselly, Eva-Laure Matera, Charles Dumontet
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2023-01-01
主題:	orthotopic subcutaneous anti-PD-1 MC38 preclinical model
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1011943/full