Deletion of soluble epoxide hydrolase attenuates mice Hyperoxic acute lung injury

Abstract Background Recent studies reported that soluble epoxide hydrolase (sEH) plays an important role in lung diseases. However, the role of sEH in hyperoxia-induced ALI is unclear. Methods ALI was induced by exposure to 100% oxygen in an airtight cage for 72 h in wild-type (WT) and sEH gene dele...

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Bibliographic Details

Published in:	BMC Anesthesiology
Main Authors:	Li-Ping Liu, Bin Li, Tian-Kui Shuai, Lei Zhu, Yu-Min Li
Format:	Article
Language:	English
Published:	BMC 2018-04-01
Subjects:	Soluble epoxide hydrolase Keap1 Nrf2 Hyperoxia Acute lung injury
Online Access:	http://link.springer.com/article/10.1186/s12871-018-0490-z