A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels

Ca2+ release-activated Ca2+ (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca2+ sensor. A hallmark of CRAC channels is fast Ca2+-dependent inactivation (CDI) which provides negative feedback to limit Ca2+ entry t...

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Bibliographic Details

Published in:	eLife
Main Authors:	Priscilla S-W Yeung, Megumi Yamashita, Murali Prakriya
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2023-02-01
Subjects:	Orai1 STIM1 CRAC channels inactivation gating store-operated calcium entry
Online Access:	https://elifesciences.org/articles/82281