NMR Insights into the Structure-Function Relationships in the Binding of Melanocortin Analogues to the MC1R Receptor

Linear and cyclic analogues of the α-melanocyte stimulating hormone (α-MSH) targeting the human melanocortin receptor 1 (MC1R) are of pharmacological interest for detecting and treating melanoma. The central sequence of α-MSH (His-Phe-Arg-Trp) has been identified as being essential for receptor bind...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Maurício Morais, Héctor Zamora-Carreras, Paula D. Raposinho, Maria Cristina Oliveira, David Pantoja-Uceda, João D. G. Correia, M. Angeles Jiménez
Format:	Article
Language:	English
Published:	MDPI AG 2017-07-01
Subjects:	α-MSH analogue cyclic peptide melanocortin receptor NMR peptide structure
Online Access:	https://www.mdpi.com/1420-3049/22/7/1189