Regulating bile acids signaling for NAFLD: molecular insights and novel therapeutic interventions

Nonalcoholic fatty liver disease (NAFLD) emerges as the most predominant cause of liver disease, tightly linked to metabolic dysfunction. Bile acids (BAs), initially synthesized from cholesterol in the liver, undergo further metabolism by gut bacteria. Increasingly acknowledged as critical modulator...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Meilin Wei, Wei Tu, Genhua Huang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-06-01
Subjects:	bile acids gut microbiota NAFLD TGR5 FXR gut liver axis
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2024.1341938/full