circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis

Abstract Background Cancer-associated fibroblasts (CAFs) are critically involved in gemcitabine (GEM) resistance in pancreatic ductal adenocarcinoma (PDAC). However, the underlying mechanism by which CAFs promote chemotherapy resistance remains unexplored. Here, we explored the role of circRNAs in C...

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Bibliographic Details

Published in:	Molecular Cancer
Main Authors:	Chonghui Hu, Renpeng Xia, Xiang Zhang, Tingting Li, Yuancheng Ye, Guolin Li, Rihua He, Zhihua Li, Qing Lin, Shangyou Zheng, Rufu Chen
Format:	Article
Language:	English
Published:	BMC 2022-01-01
Subjects:	PDAC CAFs Chemoresistance circRNAs LIF
Online Access:	https://doi.org/10.1186/s12943-022-01501-3