A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions

A live-attenuated COVID vaccine could enrich the current vaccine portfolio. Here, Liu et al. engineer a live-attenuated SARS-CoV-2 vaccine candidate by deleting four viral accessory genes and show immunogenicity and protection in mice and hamsters.

Bibliographic Details
Published in:Nature Communications
Main Authors: Yang Liu, Xianwen Zhang, Jianying Liu, Hongjie Xia, Jing Zou, Antonio E. Muruato, Sivakumar Periasamy, Chaitanya Kurhade, Jessica A. Plante, Nathen E. Bopp, Birte Kalveram, Alexander Bukreyev, Ping Ren, Tian Wang, Vineet D. Menachery, Kenneth S. Plante, Xuping Xie, Scott C. Weaver, Pei-Yong Shi
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Online Access:https://doi.org/10.1038/s41467-022-31930-z

Internet

https://doi.org/10.1038/s41467-022-31930-z

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