Unraveling the Pathogenetic Mechanisms Underlying the Association between Specific Mitochondrial DNA Haplogroups and Parkinson’s Disease

Variants of mitochondrial DNA (mtDNA) have been identified as risk factors for the development of Parkinson’s disease (PD). However, the underlying pathogenetic mechanisms remain unclear. Cybrid models carrying various genotypes of mtDNA variants were tested for resistance to PD-simulating MPP<su...

Full description

Bibliographic Details
Published in:Cells
Main Authors: Min-Yu Lan, Tsu-Kung Lin, Baiba Lace, Algirdas Utkus, Birute Burnyte, Kristina Grigalioniene, Yu-Han Lin, Inna Inashkina, Chia-Wei Liou
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Subjects:
Parkinson’s disease
mitochondrial haplogroup
cybrid
transcriptome
unfolding protein response
Online Access:https://www.mdpi.com/2073-4409/13/8/694

Internet

https://www.mdpi.com/2073-4409/13/8/694

Similar Items