Low-dose M.tb infection but not BCG or MTBVAC vaccination enhances heterologous antibody titres in non-human primates

IntroductionMycobacteria are known to exert a range of heterologous effects on the immune system. The mycobacteria-based Freund’s Complete Adjuvant is a potent non-specific stimulator of the immune response used in immunization protocols promoting antibody production, and Mycobacterium bovis Bacille...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Marco Polo Peralta Alvarez, Holly Jones, Hugo Redondo Azema, Chloe Davis, Andrew D. White, Charlotte Sarfas, Mike Dennis, Shuailin Li, Daniel Wright, Eugenia Puentes, Simon Kimuda, Sandra Belij-Rammerstorfer, Nacho Aguilo, Carlos Martin, Sally Sharpe, Helen McShane, Rachel Tanner
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	tuberculosis Mycobacterium tuberculosis BCG MTBVAC antibodies heterologous immune responses
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1387454/full