Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors

Abstract A critical step for SARS-CoV-2 assembly and maturation involves the autoactivation of the main protease (MProWT) from precursor polyproteins. Upon expression, a model precursor of MProWT mediates its own release at its termini rapidly to yield a mature dimer. A construct with an E290A mutat...

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出版年:	Communications Biology
主要な著者:	Annie Aniana, Nashaat T. Nashed, Rodolfo Ghirlando, Leighton Coates, Daniel W. Kneller, Andrey Kovalevsky, John M. Louis
フォーマット:	論文
言語:	英語
出版事項:	Nature Portfolio 2023-11-01
オンライン･アクセス:	https://doi.org/10.1038/s42003-023-05469-8