Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function

Pdx1 and Oc1 are co-expressed in multipotent pancreatic progenitors and regulate the pro-endocrine gene Neurog3. Their expression diverges in later organogenesis, with Oc1 absent from hormone+ cells and Pdx1 maintained in mature β cells. In a classical genetic test for cooperative functional interac...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Kathryn D. Henley, Diana E. Stanescu, Peter A. Kropp, Christopher V.E. Wright, Kyoung-Jae Won, Doris A. Stoffers, Maureen Gannon
Format:	Article
Language:	English
Published:	Elsevier 2016-06-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124716306234