Engineered IRES-mediated promoter-free insulin-producing cells reverse hyperglycemia

BackgroundEndogenous insulin supplementation is essential for individuals with type 1 diabetes (T1D). However, current treatments, including pancreas transplantation, insulin injections, and oral medications, have significant limitations. The development of engineered cells that can secrete endogeno...

Full description

Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Yumin Li, Doulathunnisa Ahamed Younis, Cong He, Chengming Ni, Rui Liu, Yunting Zhou, Zilin Sun, Hao Lin, Zhongdang Xiao, Bo Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-08-01
Subjects:	IRES CRISPR/Cas9 promoter-free insulin-producing cells diabetes
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2024.1439351/full