Atypical Chemokine Receptor CCRL2 Shapes Tumor Spheroid Structure and Immune Signaling in Melanoma

C-C motif chemokine receptor-like 2 (CCRL2) is an atypical chemokine receptor (ACKR) that binds chemerin with high affinity but lacks classical G protein-coupled signaling. Instead, it functions as a non-signaling presenter of chemerin to CMKLR1-expressing cells, modulating antitumor immunity. CCRL2...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Diana Al Delbany, Mai Chi Duong, Marius Regin, Arkajyoti Sarkar, Ayoub Radi, Anne Lefort, Frédérick Libert, Marc Parmentier, Claudia Spits
Format:	Article
Language:	English
Published:	MDPI AG 2025-08-01
Subjects:	CCRL2 atypical chemokine receptor tumor spheroids melanoma
Online Access:	https://www.mdpi.com/2218-273X/15/8/1150