Progress and pitfalls of gene editing technology in CAR-T cell therapy: a state-of-the-art review

CAR-T cell therapy has shown remarkable promise in treating B-cell malignancies, which has sparked optimism about its potential to treat other types of cancer as well. Nevertheless, the Expectations of CAR-T cell therapy in solid tumors and non-B cell hematologic malignancies have not been met. Furt...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Vahid Moradi, Elnaz Khodabandehloo, Mehdi Alidadi, Azadeh Omidkhoda, Naser Ahmadbeigi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-06-01
Subjects:	chimeric antigen receptor (CAR) gene editing CRISPR CAR-T cell immunotherapy cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1388475/full