IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope.

The immunoglobulins expressed by chronic lymphocytic leukemia (CLL) B cells are highly restricted, suggesting they are selected for binding either self or foreign antigen. Of the immunoglobulin heavy-chain variable (IGHV) genes expressed in CLL, IGHV1-69 is the most common, and often is expressed wi...

Full description

Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Xuchu Que, George F Widhopf, Shahzada Amir, Karsten Hartvigsen, Lotte F Hansen, Douglas Woelkers, Sotirios Tsimikas, Christoph J Binder, Thomas J Kipps, Joseph L Witztum
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0065203&type=printable