Riboswitches for Controlled Expression of Therapeutic Transgenes Delivered by Adeno-Associated Viral Vectors

Vectors developed from adeno-associated virus (AAV) are powerful tools for in vivo transgene delivery in both humans and animal models, and several AAV-delivered gene therapies are currently approved for clinical use. However, AAV-mediated gene therapy still faces several challenges, including limit...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Zachary J. Tickner, Michael Farzan
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Subjects:	adeno-associated virus gene therapy transgene aptamer riboswitch ribozyme
Online Access:	https://www.mdpi.com/1424-8247/14/6/554