New MiniPromoter Ple389 (ADORA2A) drives selective expression in medium spiny neurons in mice and non-human primates

Abstract Compact cell type-specific promoters are important tools for basic and preclinical research and clinical delivery of gene therapy. In this work, we designed novel MiniPromoters to target D1 and D2 type dopaminoceptive medium spiny neurons in the striatum by manually identifying candidate re...

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發表在:	Scientific Reports
Main Authors:	Alissandra de Moura Gomes, Terri L. Petkau, Andrea J. Korecki, Oriol Fornes, Adriana Galvan, Ge Lu, Austin M. Hill, Siu Ling Lam, Anqi Yao, Rachelle A. Farkas, Wyeth W. Wasserman, Yoland Smith, Elizabeth M. Simpson, Blair R. Leavitt
格式:	Article
語言:	英语
出版:	Nature Portfolio 2024-11-01
主題:	MiniPromoters Gene therapy Striatum Medium spiny neurons ADORA2A rAAV
在線閱讀:	https://doi.org/10.1038/s41598-024-79004-y