Antifibrotic Effects of a Barbituric Acid Derivative on Liver Fibrosis by Blocking the NF-κB Signaling Pathway in Hepatic Stellate Cells

Hepatic stellate cells (HSCs) are the major profibrogenic cells that promote the pathogenesis of liver fibrosis. The crosstalk between transforming growth factor-β1 (TGF-β1) signaling and lipopolysaccharide (LPS)-induced NF-κB signaling plays a critical role in accelerating liver fibrogenesis. Until...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Yuan-Hsi Wang, Fat-Moon Suk, Chao-Lien Liu, Tzu-Lang Chen, Yuh-Ching Twu, Ming-Hua Hsu, Yi-Jen Liao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-03-01
Subjects:	barbituric acid derivative fibrosis hepatic stellate cells liver NF-κB signaling TGF-β1/Smad
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00388/full