Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer’s disease mice by controlling astrocyte activation

Abstract Alzheimer’s disease (AD) is the most common form of dementia and is characterized by the accumulation of amyloid β (Aβ) and phosphorylated tau. Neuroinflammation, mainly mediated by glial activation, plays an important role in AD progression. Although there is growing evidence for the anti-...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Akira Sobue, Okiru Komine, Fumito Endo, Chihiro Kakimi, Yuka Miyoshi, Noe Kawade, Seiji Watanabe, Yuko Saito, Shigeo Murayama, Takaomi C. Saido, Takashi Saito, Koji Yamanaka
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-11-01
Online Access:	https://doi.org/10.1038/s41419-024-07249-6