Impact of dose feasibility on the conduct of phase I trials of adoptive cell therapy

Background: /Aims: In early-phase cell therapy trials, each dose level being studied is defined by the number of cells infused into the trial participant. The issue of dose feasibility presents itself when the desired number of cells is not reached in the expansion process. Consequently, dose assign...

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Bibliographic Details

Published in:	Contemporary Clinical Trials Communications
Main Authors:	Evan M. Bagley, Nolan A. Wages
Format:	Article
Language:	English
Published:	Elsevier 2022-02-01
Subjects:	Phase I Dose feasibility Algorithmic designs Cell therapy Dose finding
Online Access:	http://www.sciencedirect.com/science/article/pii/S2451865421001770