Personalized Human Astrocyte‐Derived Region‐Specific Forebrain Organoids Recapitulate Endogenous Pathological Features of Focal Cortical Dysplasia

Abstract Focal cortical dysplasia (FCD) is a highly heterogeneous neurodevelopmental malformation, the underlying mechanisms of which remain largely elusive. In this study, personalized dorsal and ventral forebrain organoids (DFOs/VFOs) are generated derived from brain astrocytes of patients with FC...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Jinhong Xu, Yufei Kong, Nawen Wang, Huijuan Li, Yunteng Li, Zhuo Liu, Yuling Yang, Xiao Yu, Huihui Liu, Jing Ding, Yi Wang, Rui Zhao, Zhicheng Shao
Format:	Article
Language:	English
Published:	Wiley 2025-02-01
Subjects:	disease modeling focal cortical dysplasia forebrain organoids human astrocyte induced pluripotent stem cells
Online Access:	https://doi.org/10.1002/advs.202409774