Standardization of platelet releasate products for clinical applications in cell therapy: a mathematical approach

Abstract Background Standardized animal-free components are required for manufacturing cell-based medicinal products. Human platelet concentrates are sources of growth factors for cell expansion but such products are characterized by undesired variability. Pooling together single-donor products impr...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Francesco Agostini, Jerry Polesel, Monica Battiston, Elisabetta Lombardi, Stefania Zanolin, Alessandro Da Ponte, Giuseppe Astori, Cristina Durante, Mario Mazzucato
Format:	Article
Language:	English
Published:	BMC 2017-05-01
Subjects:	Growth factors from human platelets Releasate standardization Mathematical algorithm Cell therapy Good manufacturing practice ASC ex vivo expansion
Online Access:	http://link.springer.com/article/10.1186/s12967-017-1210-z