Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity

Abstract Antibodies against phosphorylated alpha-synuclein (aSyn) at S129 have emerged as the primary tools to investigate, monitor, and quantify aSyn pathology in the brain and peripheral tissues of patients with Parkinson’s disease and other neurodegenerative diseases. Herein, we demonstrate that...

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Bibliographic Details

Published in:	npj Parkinson's Disease
Main Authors:	Hilal A. Lashuel, Anne-Laure Mahul-Mellier, Salvatore Novello, Ramanath Narayana Hegde, Yllza Jasiqi, Melek Firat Altay, Sonia Donzelli, Sean M. DeGuire, Ritwik Burai, Pedro Magalhães, Anass Chiki, Jonathan Ricci, Manel Boussouf, Ahmed Sadek, Erik Stoops, Christian Iseli, Nicolas Guex
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-10-01
Online Access:	https://doi.org/10.1038/s41531-022-00388-7