Relationship Between Time‐Varying Achieved High‐Density Lipoprotein Cholesterol and Risk of Coronary Events Depends on Haptoglobin Phenotype Within the ACCORD Lipid Study

Background The Hp (haptoglobin)2‐2 phenotype (~40% of people) is associated with dysfunctional high‐density lipoprotein (HDL) that is heavily oxidized in hyperglycemia, which may explain why raising HDL‐cholesterol (HDL‐C) does not reliably prevent coronary artery disease (CAD) in diabetes. Methods...

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Bibliographic Details

Published in:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Main Authors:	Rachel A. Warren, Allie S. Carew, Pantelis Andreou, Andrew P. Levy, John Sapp, Orit Lache, Henry N. Ginsberg, Eric B. Rimm, Christine Herman, Susan Kirkland, Leah E. Cahill
Format:	Article
Language:	English
Published:	Wiley 2023-10-01
Subjects:	coronary artery disease epidemiology genetic association HDL‐cholesterol type 2 diabetes
Online Access:	https://www.ahajournals.org/doi/10.1161/JAHA.123.030288