PKD1 mutation perturbs morphogenesis in tubular epithelial organoids derived from human pluripotent stem cells

Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal genetic disease, with most patients carrying mutations in PKD1. The main feature is the formation of bilateral renal cysts, leading to end stage renal failure in a significant proportion of those affected. Despite...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Alexandru Scarlat, Piera Trionfini, Paola Rizzo, Sara Conti, Lorena Longaretti, Matteo Breno, Lorenzo Longhi, Christodoulos Xinaris, Giuseppe Remuzzi, Ariela Benigni, Susanna Tomasoni
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-03-01
Subjects:	hiPSC Organoids ADPKD Cystogenesis
Online Access:	https://doi.org/10.1038/s41598-025-94855-9