Synthesis and evaluation of anticancer activity of quillaic acid derivatives: A cell cycle arrest and apoptosis inducer through NF-κB and MAPK pathways

A series of quillaic acid derivatives with different substituents on the 28-carboxyl group were designed and synthesized. Five human cancer cell lines (HCT116, BEL7402, HepG2, SW620, and MCF-7) were evaluated for their antitumor activity in vitro. Some of the tested derivatives showed improved antip...

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Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	Xing Huang, Chang-Hao Zhang, Hao Deng, Dan Wu, Hong-Yan Guo, Jung Joon Lee, Fen-Er Chen, Qing-Kun Shen, Li-Li Jin, Zhe-Shan Quan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	quillaic acid Western blot antitumor cell-cycle arrest apoptosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2022.951713/full