Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity
Interleukin-7 and interleukin-7 receptor are essential for normal T-cell development and homeostasis, whereas excessive interleukin-7/interleukin-7 receptor-mediated signaling promotes leukemogenesis. The protein kinase, casein kinase 2, is overexpressed and hyperactivated in cancer, including T-cel...
| 发表在: | Haematologica |
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| Main Authors: | , , , |
| 格式: | 文件 |
| 语言: | 英语 |
| 出版: |
Ferrata Storti Foundation
2016-11-01
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| 在线阅读: | https://haematologica.org/article/view/7881 |