Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc

Aims: Probucol is an anti-hyperlipidemic agent and a potent antioxidant drug that can delay progression of diabetic nephropathy (DN) and reverses renal oxidative stress in diabetic animal models; however, the mechanisms underlying these effects remain unclear. p66Shc is a newly recognized mediator o...

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Bibliographic Details

Published in:	Redox Biology
Main Authors:	Shikun Yang, Li Zhao, Yachun Han, Yu Liu, Chao Chen, Ming Zhan, Xiaofen Xiong, Xuejing Zhu, Li Xiao, Chun Hu, Fuyou Liu, Zhiguang Zhou, Yashpal S. Kanwar, Lin Sun
Format:	Article
Language:	English
Published:	Elsevier 2017-10-01
Subjects:	Probucol Renal injury Diabetic nephropathy p66Shc
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231716304256