CD47–SIRPα-targeted therapeutics: status and prospects

CD47 is a “don’t eat me” signal to phagocytes that is overexpressed on many tumor cells as a potential mechanism for immune surveillance evasion. CD47 and its interaction with signal-regulating protein alpha (SIRPα) on phagocytes is therefore a promising cancer target. Therapeutic antibodies and fus...

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Bibliographic Details

Published in:	Immuno-Oncology and Technology
Main Authors:	R. Maute, J. Xu, I.L. Weissman
Format:	Article
Language:	English
Published:	Elsevier 2022-03-01
Subjects:	CD47 SIRPα magrolimab macrophage phagocytosis innate immunotherapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590018822000016