Activation and Purification of ß‐Glucocerebrosidase by Exploiting its Transporter LIMP‐2 – Implications for Novel Treatment Strategies in Gaucher's and Parkinson's Disease

Abstract Genetic variants of GBA1 can cause the lysosomal storage disorder Gaucher disease and are among the highest genetic risk factors for Parkinson's disease (PD). GBA1 encodes the lysosomal enzyme beta‐glucocerebrosidase (GCase), which orchestrates the degradation of glucosylceramide (GluC...

Full description

Bibliographic Details

Published in:	Advanced Science
Main Authors:	Jan Philipp Dobert, Simon Bub, Rebecca Mächtel, Dovile Januliene, Lisa Steger, Martin Regensburger, Sibylle Wilfling, Jia‐Xuan Chen, Mario Dejung, Sonja Plötz, Ute Hehr, Arne Moeller, Philipp Arnold, Friederike Zunke
Format:	Article
Language:	English
Published:	Wiley 2024-07-01
Subjects:	β‐glucocerebrosidase Gaucher's disease (GD) GCase LIMP‐2 lysosomes Parkinson's disease (PD)
Online Access:	https://doi.org/10.1002/advs.202401641