Taxifolin attenuates liver fibrosis by regulating the phosphorylation of NDRG1 at Thr328 via hepatocyte-stellate cell cross talk

Taxifolin (TAX) is a natural compound known for its liver protection effect, but the mechanism remains unknown. Phosphorylated proteomics analyses discovered that the phosphorylation level of NDRG1 at T328 was a key event of TAX-improved liver fibrosis. We established models with NDRG1 knockout (KO)...

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出版年:	Acta Pharmaceutica Sinica B
主要な著者:	Chuan Ding, Zeping Wang, Kao Shi, Sunan Li, Xinyue Dou, Yan Ning, Gang Cheng, Qiao Yang, Xianan Sang, Mengyun Peng, Qiang Lyu, Lu Wang, Xin Han, Gang Cao
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2025-04-01
主題:	Taxifolin Liver fibrosis pNDRG1T328 Hepatocyte Liver injury HSCs
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211383525000905