Pleiotropic prodrugs for both symptomatic and disease-modifying treatment of Alzheimer’s disease

The inherent complexity of Alzheimer’s disease (AD) and failed clinical trials have spiked the interest in multifunctional ligands that target at least two key disease-associated macromolecules in AD pathology. Here we present a focused series of pleiotropic N-carbamoylazole prodrugs with dual mecha...

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發表在:	Acta Pharmaceutica Sinica B
Main Authors:	Anže Meden, Neža Žnidaršič, Damijan Knez, Yuanyuan Wang, Ziwei Xu, Huajing Yang, Weiting Zhang, Anja Pišlar, Andrej Perdih, Simona Kranjc Brezar, Neža Grgurevič, Stane Pajk, Haopeng Sun, Stanislav Gobec
格式:	Article
語言:	英语
出版:	Elsevier 2025-09-01
主題:	Pleiotropic prodrug Alzheimer’s disease Butyrylcholinesterase α2A adrenoreceptor Disease-modifying treatment N-Heterocyclic ureas
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2211383525004605