Distinct maturity and spatial distribution of tertiary lymphoid structures in head and neck squamous cell carcinoma: implications for tumor immunity and clinical outcomes

Abstract The influence of tertiary lymphoid structures (TLSs) on disease progression and the response to immunotherapy in head and neck squamous cell carcinoma (HNSCC) is well established, yet the heterogeneity among these structures remains largely unexplored. We utilized digital spatial profiling...

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Bibliographic Details

Published in:	Cancer Immunology, Immunotherapy
Main Authors:	Shuai Xu, Chao Han, Jian Zhou, Di Yang, Hui Dong, Yiwei Zhang, Tingting Zhao, Yi Tian, Yuzhang Wu
Format:	Article
Language:	English
Published:	Springer 2025-02-01
Subjects:	Tertiary lymphoid structures Head and neck squamous cell carcinoma Maturation stage of TLSs Spatial distribution of TLSs TLS scoring system
Online Access:	https://doi.org/10.1007/s00262-025-03952-1