Lipid Nanoparticles Deliver the Therapeutic VEGFA mRNA In Vitro and In Vivo and Transform Extracellular Vesicles for Their Functional Extensions

Abstract Lipid nanoparticles (LNPs) are currently used to transport functional mRNAs, such as COVID‐19 mRNA vaccines. The delivery of angiogenic molecules, such as therapeutic VEGF‐A mRNA, to ischemic tissues for producing new blood vessels is an emerging strategy for the treatment of cardiovascular...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Muhammad Nawaz, Sepideh Heydarkhan‐Hagvall, Benyapa Tangruksa, Hernán González‐King Garibotti, Yujia Jing, Marco Maugeri, Franziska Kohl, Leif Hultin, Azadeh Reyahi, Alessandro Camponeschi, Bengt Kull, Jonas Christoffersson, Ola Grimsholm, Karin Jennbacken, Martina Sundqvist, John Wiseman, Abdel Wahad Bidar, Lennart Lindfors, Jane Synnergren, Hadi Valadi
Format:	Article
Language:	English
Published:	Wiley 2023-04-01
Subjects:	endocytosis extracellular vesicles in vivo lipid nanoparticles LNP‐mRNA luciferase mRNA
Online Access:	https://doi.org/10.1002/advs.202206187