Network Architecture and Mutational Sensitivity of the C. elegans Metabolome

A fundamental issue in evolutionary systems biology is understanding the relationship between the topological architecture of a biological network, such as a metabolic network, and the evolution of the network. The rate at which an element in a metabolic network accumulates genetic variation via new...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Lindsay M. Johnson, Luke M. Chandler, Sarah K. Davies, Charles F. Baer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-07-01
Subjects:	metabolic network mutation accumulation mutational correlation mutational variance network centrality
Online Access:	https://www.frontiersin.org/article/10.3389/fmolb.2018.00069/full