LncRNA IRAIN overcomes imatinib resistance in chronic myeloid leukemia via NF-κB/CD44 pathway inhibition

Summary: The development of tyrosine kinase inhibitors (TKIs) has revolutionarily increased the overall survival of patients with chronic myeloid leukemia (CML). However, drug resistance remains a major obstacle. Here, we demonstrated that a BCR-ABL1-independent long non-coding RNA, IRAIN, is consti...

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Bibliographic Details

Published in:	iScience
Main Authors:	Xijia Wang, Yutong Hou, Yizhu Lyu, Jiayin Zhou, Xin Zhang, Mohammad Arian Hassani, Dan Huang, Zhijia Zhao, Dong Zhou, Fang Xie, Xuehong Zhang, Jinsong Yan
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	Molecular biology Cell biology Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224010733