BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A

The health of neurons is critically dependent on the relative signaling intensities of survival-promoting synaptic and death-inducing extrasynaptic NMDA receptors. Here, we show that BDNF is a regulator of this balance and promotes neuroprotection by reducing toxic NMDA receptor signaling. BDNF acts...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	David Lau, C. Peter Bengtson, Bettina Buchthal, Hilmar Bading
Format:	Article
Language:	English
Published:	Elsevier 2015-08-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124715007986