A Proposal for a Structural Model of the Feline Calicivirus Protease Bound to the Substrate Peptide under Physiological Conditions

Feline calicivirus (FCV) protease functions to cleave viral precursor proteins during productive infection. Previous studies have mapped a protease-coding region and six cleavage sites in viral precursor proteins. However, how the FCV protease interacts with its substrates remains unknown. To gain i...

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發表在:	Frontiers in Microbiology
Main Authors:	Masaru Yokoyama, Tomoichiro Oka, Hirotaka Takagi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yukinobu Tohya, Hironori Sato
格式:	Article
語言:	英语
出版:	Frontiers Media S.A. 2017-07-01
主題:	feline calicivirus protease in silico screening 3-D pharmacophore BRET technology MD simulation
在線閱讀:	http://journal.frontiersin.org/article/10.3389/fmicb.2017.01383/full