A Proposal for a Structural Model of the Feline Calicivirus Protease Bound to the Substrate Peptide under Physiological Conditions

Feline calicivirus (FCV) protease functions to cleave viral precursor proteins during productive infection. Previous studies have mapped a protease-coding region and six cleavage sites in viral precursor proteins. However, how the FCV protease interacts with its substrates remains unknown. To gain i...

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الحاوية / القاعدة:	Frontiers in Microbiology
المؤلفون الرئيسيون:	Masaru Yokoyama, Tomoichiro Oka, Hirotaka Takagi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yukinobu Tohya, Hironori Sato
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2017-07-01
الموضوعات:	feline calicivirus protease in silico screening 3-D pharmacophore BRET technology MD simulation
الوصول للمادة أونلاين:	http://journal.frontiersin.org/article/10.3389/fmicb.2017.01383/full