Bilirubin Restrains the Anticancer Effect of Vemurafenib on BRAF-Mutant Melanoma Cells Through ERK-MNK1 Signaling

Melanoma, the most threatening cancer in the skin, has been considered to be driven by the carcinogenic RAF-MEK1/2-ERK1/2 signaling pathway. This signaling pathway is usually mainly dysregulated by mutations in BRAF or RAS in skin melanomas. Although inhibitors targeting mutant BRAF, such as vemuraf...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Yufan Tan, Xiaoyu Zhong, Xizhi Wen, Leyi Yao, Zhenlong Shao, Wenshuang Sun, Jiawen Wu, Guanmei Wen, Daolin Tang, Xiaoshi Zhang, Yuning Liao, Jinbao Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-06-01
Subjects:	bilirubin vemurafenib ERK MNK1 BRAF-mutant melanoma
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2021.698888/full