2,4-Disubstituted pyridine derivatives are effective against intracellular and biofilm-forming tubercle bacilli

It was recently reported that 4-substituted picolinohydrazonamides carrying hydrophilic cyclic amines, such as morpholine and pyrrolidine, at the end of their thiosemicarbazide chain have potent antimycobacterial activity in vitro at concentrations below 1 μg/ml. Here, two selected compounds, 2,4-di...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	M. Korycka-Machała, M. Kawka, J. Lach, R. Płocińska, A. Bekier, B. Dziadek, A. Brzostek, P. Płociński, D. Strapagiel, M. Szczesio, K. Gobis, J. Dziadek
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	pyridine derivatives tuberculosis drug resistance Mtb inhibitors MmpR5 biofilm
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1004632/full